Journal: bioRxiv
Article Title: Xylazine Exacerbates Fentanyl-Induced Respiratory Depression and Bradycardia
doi: 10.1101/2024.08.16.608310
Figure Lengend Snippet: A) Graphical representation of study design. Blood oxygen saturation and heart rate of male and female CD-1 mice (n=6 per group) were measured using the MouseOx ® pulse oximetry system according to the timeline shown. B-C) Arrows and dotted lines indicate i.p. injection point. Area under the curve was compared independently among all 6 groups via two-way ANOVA (t=0-60 min; main effect of treatment p<0.0001 for both parameters). Area under the curve values by treatment group from t=0-60 min post-injection were compared via one-way ANOVA (p<0.0001 for both parameters) with Tukey’s post-hoc test (p-values displayed in bar graph). B) Time course of blood oxygen saturation (%) by treatment group with a bar graph displaying area under the curve values from t=0-60 min post-injection (average ± S.E.M.). C) Time course of heart rate by treatment group with a bar graph displaying area under the curve values from t=0-60 min post-injection (average ± S.E.M.). ****p<0.0001 vs. vehicle; ⊹ p<0.05, ⊹⊹ p<0.01, ⊹⊹⊹⊹ p<0.0001 vs. fentanyl alone
Article Snippet: Blood oxygen saturation and heart rate were measured using the MouseOx ® Plus Small Animal Pulse Oximeter from Starr Life Sciences (Oakmont, PA).
Techniques: Injection